Topic: Synthesis of Penta- and Tetra-fluorosulfanyl Molecules for Sustainable Society

Reporter: Prof. Norio Shibata, Nagoya Institute of Technology

Time: Agust, 6, 2024 (10:00-11:30), UTC+8

Venue: Meeting Room 201 of School of Chemistry, Chemical Engineering and Life Science

Abstract:

The development of innovative synthetic methodologies for diversifying fluorinated structural motifs is crucial for drug discovery, as it expands the range of accessible molecules. Moreover, novel alternatives to popular fluorinated units, such as trifluoromethyl (-CF3) and difluoromethylene (-CF2-), have received increasing attention as environmentally benign fluorinated functional groups in the future market, as the use of molecules containing -CF3 and -CF2- is going to be discussed, such as PFAS. Particularly for agrochemical design, the use of CF3 and related fluorinated functional groups in drugs is controversial because of their degradation to highly acidic residues such as trifluoroacetic acid. In this context, lipophilic, hexacoordinate sulfur-fluorine analogs such as pentafluoro-sulfanyl (-SF5) and tetrafluoro-sulfanyl (-SF4-) units have received increasing attention as environmentally benign fluorinated functional groups.

Biography: 

Norio Shibata has been a professor of chemistry at Nagoya Institute of Technology since 2008. He received his Ph.D. (1993) in Pharmaceutical Sciences from Osaka University under the supervision of Professor Yasuyuki Kita. He worked at the Dyson Perrins Laboratory (Professor Sir Jack E. Baldwin) in Oxford University (JSPS Fellow, 1994-1996), Sagami Chemical Research Institute (Dr. Shiro Terashima, 1996), after which he was a lecturer at Toyama Medical & Pharmaceutical University (1997-2003) and an associate professor at Nagoya Institute of Technology (2003-2008). He received “The Society of Iodine Science Award (2019)”, “Fellow of Royal Society of Chemistry (2021, RSC, UK)” and “Chair of Excellence (LabEx SynOrg, France, 2022-2023)”. He is a member of the ACS Fluorine Division Committee (2015-2017), a Visiting Professor at the University of Rouen (2008, 2012) and Zhejiang Normal University (2017-2019), Academic Visitor at the University of Oxford (2017, 2018), University of Valencia (2017, 2019), Senior Technical Consultant at the National Engineering Technology Center of Fluoro Materials, Juhua Group Corporation (2017-2019), and Visiting Professor at the University of Münster (2024). His research interests cover a wide range of synthetic and medicinal fluorine chemistry.

Edited by: Li Tiantian

Source: School of Chemistry, Chemical Engineering and Life Science